Publications
UK Biobank papers involving Manchester researchers
A selection of published papers illustrating the breadth of research taking place within the University's UK Biobank Community, organised by organ systems and topic.
If you would like your study to be featured on this page, please email Natalie.Theodoulou@manchester.ac.uk (Research Development and Innovation Manager).
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Sleep
Biological and clinical insights from genetics of insomnia symptoms
[Lane JM, Jones SE, Dashti HS, et al. Nat Genet. Mar 2019;51(3):387-393. doi:10.1038/s41588-019-0361-7]Sleep regularity is a stronger predictor of mortality risk than sleep duration: A prospective cohort study
[Windred DP, Burns AC, Lane JM, et al. Sleep. Jan 11 2024;47(1)doi:10.1093/sleep/zsad253] -
Brain
Inflammation and Brain Structure in Schizophrenia and Other Neuropsychiatric Disorders: A Mendelian Randomization Study
[Williams JA, Burgess S, Suckling J, et al. JAMA Psychiatry. May 1 2022;79(5):498-507. doi:10.1001/jamapsychiatry.2022.0407]Multiple lifestyle factors and depressed mood: a cross-sectional and longitudinal analysis of the UK Biobank (N = 84,860)
[Sarris J, Thomson R, Hargraves F, et al. BMC Med. Nov 12 2020;18(1):354. doi:10.1186/s12916-020-01813-5]More publications
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Circadian Rhythms
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
[Jones SE, Lane JM, Wood AR, et al. Nat Commun. Jan 29 2019;10(1):343. doi:10.1038/s41467-018-08259-7] -
Heart
Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure
[Siedlinski M, Carnevale L, Xu X, et al. Eur Heart J. Jun 20 2023;44(23):2114-2125. doi:10.1093/eurheartj/ehad101]Sleep Duration and Myocardial Infarction
[Daghlas I, Dashti HS, Lane J, et al. J Am Coll Cardiol. Sep 10 2019;74(10):1304-1314. doi:10.1016/j.jacc.2019.07.022] -
Lung
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
[Sakornsakolpat P, Prokopenko D, Lamontagne M, et al. Nat Genet. Mar 2019;51(3):494-505. doi:10.1038/s41588-018-0342-2] -
Breast
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
[Mavaddat N, Michailidou K, Dennis J, et al. Am J Hum Genet. Jan 3 2019;104(1):21-34. doi:10.1016/j.ajhg.2018.11.002]Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study
[Dixon-Suen SC, Lewis SJ, Martin RM, et al. Br J Sports Med. Oct 2022;56(20):1157-1170. doi:10.1136/bjsports-2021-105132] -
Pancreas (Diabetes)
Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank
[Vetter C, Dashti HS, Lane JM, et al. Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank. Diabetes Care. Apr 2018;41(4):762-769. doi:10.2337/dc17-1933] -
Liver
Shift work and evening chronotype are associated with hepatic fat fraction and non-alcoholic fatty liver disease in 282,303 UK biobank participants
[Maidstone R, Rutter MK, Marjot T, Ray DW, Baxter M. Endocr Connect. Feb 1 2024;13(2)doi:10.1530/ec-23-0472] -
Kidney
Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease
[Zheng J, Zhang Y, Rasheed H, et al. Int J Epidemiol. Jan 6 2022;50(6):1995-2010. doi:10.1093/ije/dyab203] -
Bone
Machine Learning-Derived Acetabular Dysplasia and Cam Morphology Are Features of Severe Hip Osteoarthritis: Findings From UK Biobank
[Frysz M, Faber BG, Ebsim R, et al. J Bone Miner Res. Sep 2022;37(9):1720-1732. doi:10.1002/jbmr.4649] -
Bladder
A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
[Farazi M, Yang X, Gehl CJ, et al. Cancer Epidemiol Biomarkers Prev. May 2 2025;34(5):795-804. doi:10.1158/1055-9965.Epi-24-1228] -
Skin
Association of Lipid-Lowering Drugs With Risk of Psoriasis: A Mendelian Randomization Study
[Zhao SS, Yiu ZZN, Barton A, Bowes J. JAMA dermatology. Mar 1 2023;159(3):275-280. doi:10.1001/jamadermatol.2022.6051] -
Occupational exposures
Lifetime occupational exposures and chronic obstructive pulmonary disease risk in the UK Biobank cohort
[De Matteis S, Jarvis D, Darnton L, et al. Thorax. Oct 2022;77(10):997-1005. doi:10.1136/thoraxjnl-2020-216523] -
Obesity
Adiposity and grip strength: a Mendelian randomisation study in UK Biobank
[Pinto Pereira SM, Garfield V, Farmaki AE, et al. BMC Med. Jun 2 2022;20(1):201. doi:10.1186/s12916-022-02393-2] -
Genetics
The trans-ancestral genomic architecture of glycemic traits
[Chen J, Spracklen CN, Marenne G, et al. Nat Genet. 2021 Jun;53(6):840-860. doi: 10.1038/s41588-021-00852-9. Epub 2021 May 31. PMID: 34059833; PMCID: PMC7610958]Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
[Evangelou E, Warren HR, Mosen-Ansorena D, et al. Nat Genet. 2018 Oct;50(10):1412-1425. doi: 10.1038/s41588-018-0205-x. Epub 2018 Sep 17. Erratum in: Nat Genet. 2018 Dec;50(12):1755. doi: 10.1038/s41588-018-0297-3. PMID: 30224653; PMCID: PMC6284793] -
Proteomics
Circulating inflammatory and immune response proteins and endometrial cancer risk: a nested case-control study and Mendelian randomization analyses
[Wang SE, Viallon V, Lee M, et al. EBioMedicine. 2024 Oct;108:105341. doi: 10.1016/j.ebiom.2024.105341. Epub 2024 Sep 14. PMID: 39278107; PMCID: PMC11418138]Evaluation of associations between genetically predicted circulating protein biomarkers and breast cancer risk
[Shu X, Bao J, Wu L, et al. Int J Cancer. 2020 Apr 15;146(8):2130-2138. doi: 10.1002/ijc.32542. Epub 2019 Jul 16. PMID: 31265136] -
Metabolomics
An atlas of genetic scores to predict multi-omic traits
Xu Y, Ritchie SC, Liang Y, et al. Nature. 2023 Apr;616(7955):123-131. doi: 10.1038/s41586-023-05844-9. Epub 2023 Mar 29. PMID: 36991119; PMCID: PMC10323211.Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome
McGurk KA, Williams SG, Guo H, et al. Hum Mol Genet. 2021 Apr 30;30(6):500-513. doi: 10.1093/hmg/ddab002. PMID: 33437986; PMCID: PMC8101358. -
Activity monitoring
Impaired Rest-Activity Rhythm Characteristics Predict Higher Risk of Incident Type 2 Diabetes in UK Biobank Participants
[Yeung CHC, Wright AK, Windred DP, et al. Diabetes Care. 2025 Aug 1;48(8):1425-1433. doi: 10.2337/dc25-0309. PMID: 40569828; PMCID: PMC12281981]PHOSP-COVID Study Collaborative Group. Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
[Jackson C, Stewart ID, Plekhanova T, et al. Lancet Respir Med. 2023 Aug;11(8):673-684. doi: 10.1016/S2213-2600(23)00124-8. Epub 2023 Apr 15. PMID: 37072018; PMCID: PMC10156429]
