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How do skin lipids and bacteria change with age?

Description

Iras : 252737

Determining the critical relationship between human epidermal lipids and microbiota in sustaining healthy skin ageing

As skin ages, we see a decline in skin barrier function, which can leave elderly people vulnerable to skin damage. We believe that these changes may partly be due to changes in the skin’s lipid profile, and changes in the bacteria living on the skin.

In this study, we plan to investigate how the skin lipids and bacteria change as we age, by recruiting volunteers in two different age groups (18-40 and over 70). We will examine the lipid composition of the skin, the function of the skin barrier, and the number and type of microbes that are found on the skin, at different body sites. We hope to identify changes in these profiles, and the relationship between the two.

 

Who can take part?

Healthy men and women aged 18-40 or over 70.

 

What will the research involve?

This study will involve a single visit to the study clinic. During this visit you will have your skin health assessed (including measurements of pH and water loss), then we will use wet swabs to sample surface bacteria, adhesive tape strips to sample the very top layer of your skin, and we will also take two skin biopsies (6 mm diameter) from the buttock skin of some volunteers.

 

Where will the research take place?

Salford Royal Hospital

 

Reimbursement

You will be reimbursed for your time and inconvenience.

 

 

 

Contact details

 susan.hawksworth@manchester.ac.uk

Tel: 0161 206 8526.