Exploring hormonal-related activity in skin immune responses. How does our skin change with age and hormonal imbalance?

Description

Study summary

During menopause, women experience hormonal changes, particularly a decrease in oestrogen levels, which can lead to a decline in skin health and vitality.

The aim of this study is to investigate how hormonal changes during menopause impact the cells of the immune system in the skin, by recruiting healthy female White Caucasian volunteers aged 18-80, including post-menopausal women who are undergoing hormone replacement therapy. We will investigate the quantity and function of immune cells in both the skin and blood, with a particular focus on exploring the relationship between these cells and the overall functionality of the skin barrier.

Who can take part?

Healthy White Caucasian women aged 18-80 with a skin prototype I-III (sun-sensitive).

What will the research involve?

Subjects interested in participating in this study will be required to complete an online questionnaire and make three visits to the study unit. During these visits, your skin health will be assessed through measurements of pH, water loss, hydration, elasticity and skin ageing markers. Additionally, UV radiation will be applied to your skin. Blood samples and 6 mm skin biopsies will be taken from your buttock skin.

Where will the research take place?

You will need to complete a questionnaire online and then attend a unit at Salford Royal Hospital for three visits. These visits will take place over three consecutive days, with an additional appointment for stitch removal.

Reimbursement

You will be reimbursed for your time and inconvenience.

Interested?

If you are interested in finding out more, please contact Lydia Ward; Tel: 0161 306 3309; Email: Lydia.Ward@manchester.ac.uk OR Rajia Bahri; Email: Rajia.Bahri@manchester.ac.uk at the Dermatopharmacology Unit, Salford Royal Hospital

Contact details

Lydia Ward, Lydia.ward@manchester.ac.uk, 0161 306 3309